Create two (or more) virtual disks, then depending on whether you run virt-manager or the command line it is just a matter of specifying the same serial number.
virt-manager serial number
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qemu-kvm
qemu-kvm ... -device ... -drive if=none,id=sda,file=disk1.img,serial=0001 ... -device -drive if=none,id=sdb,file=disk1.img,serial=0001 ...
Result for libvirt's xml code for KVM guest
...
<devices>
...
<disk type='block' device='disk'>
 ...
 <serial>0001</serial>
 ...
</disk>
<disk type='block' device='disk'>
 ...
 <serial>0001</serial>
 ...
</disk>